S-nitrosothiols as vasodilators: implications regarding tolerance to nitric oxide-containing vasodilators

Two aerosolized nitric oxide adducts as selective pulmonary vasodilators for acute pulmonary hypertension.

STUDY OBJECTIVES To determine the selective vasodilatory effects of two inhaled "NONOate" aerosols in a closed chest pig model of acute pulmonary hypertension (APH). METHODS APH was induced by IV infusion of the prostaglandin H(2)/thromboxane A(2) receptor agonist (U46619). Aerosolized diethylenetriamine nitric oxide (NO) adduct (DETA/NO, n = 4), dipropylenetriamine NO adduct (DPTA/NO, n = 4)...

Pulmonary vasodilators.

Pulmonary vasodilators are an important treatment for pulmonary arterial hypertension. They reduce pulmonary artery pressure; improve hemodynamic function; alter ventilation/perfusion matching in the lungs; and improve functional quality of life, exercise tolerance, and survival in patients with severe pulmonary arterial hypertension. This paper reviews the currently available pulmonary vasodil...

The Release of Nitric Oxide from S-Nitrosothiols Promotes Angiogenesis

BACKGROUND Free nitric oxide (NO) reacts with sulphydryl residues to form S-nitrosothiols, which act as NO reservoirs. We sought to determine whether thiol-preserving agents and antioxidants, such as dithiothreitol (DTT) and vitamin C, induce NO release from S-nitrosylated proteins in endothelial cell cultures to promote angiogenesis. METHODOLOGY/PRINCIPAL FINDINGS NO release was measured dir...

Vasodilators in pulmonary hypertension.

Antianginal Agents and Vasodilators

“We now know that the coronary blood vessels in the atherosclerotic heart already are dilated and that ordinary doses of dilator drugs do not significantly increase blood supply to the heart; instead, anginal pain is relieved by a reduction of cardiac consumption of oxygen.” Although vasodilators are used in the treatment of angina, a more sophisticated understanding of the hemodynamic response...